Structural Similarities between Glutamate Receptor Channels and K+ Channels Examined by Scanning Mutagenesis

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Structural Similarities between Glutamate Receptor Channels and K 1 Channels Examined by Scanning Mutagenesis ✪

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Structural Similarities between Glutamate Receptor Channels and K+ Channels Examined by Scanning Mutagenesis

The pores of glutamate receptors and K(+) channels share sequence homology, suggesting a conserved secondary structure. Scanning mutagenesis with substitution of alanine and tryptophan in GluR6 channels was performed based on the structure of KcsA. Our assay used disruption of voltage-dependent polyamine block to test for changes in the packing of pore-forming regions. Alanine scanning from D56...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 2001

ISSN: 0022-1295,1540-7748

DOI: 10.1085/jgp.117.4.345